RM Tests offered

[Not all the investigations are specific to recurrent miscarriage - some are general health checks, while others are part of our on-going programme of research].

  • Chromosome studies - this is based on a blood test, and both partners are tested.
  • Specific immunological testing: (conducted as part of our on-going research programme): Natural killer cells - numbers and activation Cytokines - especially MIC-1and Th1 and Th2 cytokines
  • Auto-immune screen - includes anti-nuclear antibodies, and anti-dsDNA antibodies
  • Infection screen - a vaginal swab for bacterial vaginosis, and cervical swab for Chlamydia
  • Primary antiphospholipid syndrome (so-called "sticky blood syndrome") screen - including anticardiolipin antibody and lupus anticoagulant.
  • Full thrombophilia screen (including Factor V Leiden mutation)
  • Pelvic ultrasound scan - usually transvaginal
  • Day 3-4 blood test for a hormonal profile to include luteinising hormone (LH), follicle stimulating hormone (FSH), prolactin, testosterone and sex hormone binding globulin (SHBG), and thyroid function.
  • A biochemical profile to include a blood sugar, kidney and liver function.
  • Women who have suffered late miscarriage (14-24 weeks), and those in whom ultrasound scan suggests a lesion inside the womb such as a fibroid, polyp or septum will be offered a hysteroscopy. This is a surgical procedure which involved the insertion of a special camera (a hysteroscope) into the womb via the vagina and cervix. This is usually performed as a day case, and usually under local anaesthesia, but if a fibroid inside the womb needs to be shaved away then this may be performed under general anaesthesia, although still as a day case.